And except you may have a physician-diagnosed deficiency in any of those nutrients that you can’t fill with meals alone, there’s no real have to complement in any respect. "At finest, super-high doses of nutrients are buying you expensive urine, and at worst, they might contribute to the event of chronic diseases," she says. While research show supplementing with excessive doses does help construct muscle mass and enhance power over time, it’s not pre-workout within the strict sense, in that timing doesn’t really matter. Taking smaller doses more often through the day might even be an choice, but you need to talk about any changes in your remedy timing or dosage with your physician earlier than experimenting on your own. For instance, a 2017 study within the Journal of Clinical Oncology discovered that lengthy-term supplementation with excessive doses of vitamin B6 and B12 could considerably increase the danger of lung most cancers in males